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KMID : 0613820130230091163
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Journal of Life Science
2013 Volume.23 No. 9 p.1163 ~ p.1169
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Fagopyritol, a Derivative of D-chiro-inositol, Induces GLUT4 Translocation via Actin Filament Remodeling in L6-GLUT4myc Skeletal Muscle Cells
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Nam Ha-Jin
Hwang In-Koo
Jung Ha-rry
Kwon Seung-Hae
Park Ok-Kyu
Suh Jun-Gyo
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Abstract
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Insulin induces glucose transporter 4 (GLUT4) translocation to the muscle cell surface. As fagopyritol has insulin-like effects, the effects of fagopyritol on GLUT4 translocation and filamentous (F) actin remodeling in L6-GLUT4myc skeletal muscle cells were investigated. Fagopyritol significantly increased plasma membrane GLUT4 levels compared with the basal control in L6-GLUT4myc myoblast cells. Phosphatidylinositol (PI) 3-kinase inhibitor (LY294002) treatment prevented GLUT4 translocation to the plasma membrane in the myoblasts. Fagopyritol treatment apparently stimulates F-actin remodeling in myoblasts. In addition, fagopyritol treatment induced GLUT4 translocation and F-actin remodeling in myotubes. Taken together, these results suggest that fagopyritol promotes GLUT4 translocation and F-actin remodeling by activating the PI 3-kinase-dependent signaling pathway.
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KEYWORD
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Fagopyritol, Glucose transporter 4 (GLUT4) translocation, Actin filament, D-chiro-inositol, L6-GLUT4myc myoblasts
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